When Egg & Sperm Don't Hook Up

It's pretty amazing what is still being learned about the most basic points along the conception trail. The big news recently is about a molecule that helps sperm cells bind to egg cells.

Researchers are calling it SLeX, short for sialyl-LewisX. Their study found SLeX on 70% of the 195 unfertilised eggs tested. If your egg cells don't have SLeX, sperm cells won't connect to it for the mating game. The best news: the authors of the study, who came from Britain, Taiwan, and the U.S., believe this discovery might lead to related infertility treatments in only about two years.

But what about in the meantime? While clinical diagnosis of this condition may be a couple of years away, the treatment for women with missing SLex is already available.

Intractytoplasmic sperm injection, or ICSI, is available for patients whose infertility is caused by lack of SLeX, as well as other causes. ICSI is one of assisted reproduction's most fascinating treatments -- a single sperm cell actually being injected into an egg cell. And while it may sound like science fiction, ICSI is no longer experimental. In fact, ICSI's been around for decades now and used with great success in conjunction with IVF. In 2008, staff of Houston Fertility Center had a related poster presentation accepted for that year's meeting of the American Society for Reproductive Medicine. Our study concluded that patients using ICSI had higher implantation rates.

One of the most incredible uses of ICSI is to treat even the most severe forms of male factor infertility. Since IVF with ICSI requires only one good sperm cell, the treatment has made biological dads out of men who previously had nearly no chance of having offspring.

Developments from our greater understanding of how SLeX can make or break conception attempts might lead to quicker, more direct diagnosis for couples with unexplained infertility. Every little detail makes a difference.

~Dr. Sonja Kristiansen, MD

Weight Issues & Fertility Not Just a Woman's Concern

Here we are again -- the end of year holidays. This time can have a real double whammy effect on people trying to conceive. First, there are the joyous gatherings... with babies everywhere. Then, there's the abundance of food, much of it rich and not-so-nutritious. You know, the kind that's so much fun to enjoy too much of...

Why is food a problem for people trying to get pregnant?

By now you've probably heard about the impact that weight has on a woman's fertility -- both too little and too much weight can result in ovulation disorders. Also, overweight women increase their surgical risks even for procedures as commonplace as egg retrieval. But there's more research now that says men need to keep an eye on their fatty food intake, too.

At this year's meeting of the American Society for Reproductive Medicine, researchers presented evidence that men with the highest intake of saturated fat had 41% fewer sperm than those who ate less. Also, men who ate more omega-6 and omega-3 polyunsaturated fats, specifically, had better sperm motility and morphology.

There is some good news on the research front for men who are overweight. The low testosterone levels that apparently go along with high BMI (body mass index) do respond positively to clomiphene citrate (Clomid).

But on this eve of one of our country's biggest binge-eating holidays, I'd recommend having a double helping of the carrots and lay off the gravy a little bit.

Also see:

When Fertility Really Is About Your Diet

Weight & Fertility (from my April 2007 newsletter)

Translating Molecular Science: Marijuana Use Slows Down Sperm

This article in Scientific American is rather complex reading but reveals some important findings. One of the items in the piece, about study results just published in the journal Cell, is tucked in at the very end -- which is too bad, because it's a tidbit of data that even the least technical reader can grasp.

According to researcher Yurij Kirichok of the University of California at San Francisco, "Marijuana likely activates sperm prematurely, leaving them burnt out in a matter of hours."

Importantly, this study was not about marijuana's effects on male fertility. Rather, the researchers were investigating molecular components that impact how and when a sperm cell gets moving. Besides pinpointing a molecule (Hv1) that activates a resting sperm cell, they also found a few more pieces to the puzzle linking marijuana and male infertility, via endocabbinoids.

Too much medical geek talk? Just simplify it to what we typically recommend: avoiding toxins of all kinds can enhance fertility.